- DistilBio is a search engine for life sciences data, designed for biologists and bioinformaticians.
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Category Archives: Use case
Compound searches and their bio-activities in DistilBio
In my previous posts, I had focused on queries for drugs, diseases and proteins using DistilBio. Apart from this, DistilBio also contains data on bioactive chemical compounds from databases like ChEMBL and ChEBI. Experimental data properties, assays, cell line information … Continue reading
Posted in DistilBio, Use case
Tagged aromatase, assay, breast cancer, cell line, Chebi, Chembl, chemical compound, chemspider, compound, CP19A, DistilBio, drug discovery, letrozole, patent, tissue
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Aspirin – Old drug, new roles?
In my last post, I looked at the different mechanism of actions of 3 OTC drugs – Aspirin, Acetaminophen and Ibuprofen. Aspirin a drug discovered ~100 years ago and in use for more than 50 years is one of the … Continue reading
Posted in Use case
Tagged acetaminophen, angiogenesis, aspirin, breast cancer, cancer, colorectal cancer, COX1, cox2, DistilBio, egfr, erk1, erk2, ibuprofen, il4, mapk, Myocardial Infarction, ovarian cancer, pancreatic cancer, pkc, raf, ras, renal cell carcinoma
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Drug Re-purposing – DistilBio Use Case
A very interesting and new approach adopted by Pharma companies is Drug re-purposing or re-positioning. Drug re-purposing is the use of already approved drug for disease indications that they were not initially developed to combat. This means that the drugs … Continue reading
Disease to Drug and Molecular Side Effects – DistilBio Use Case
Since my last post on Drug target search for Sitagliptin, I have been thinking about other ways to verify the results I got using DistilBio. One of the things that came to my mind was to work backwards from diabetes … Continue reading
Posted in DistilBio, Use case
Tagged DistilBio, drug side effects, drug target search, Gene Ontology, use case
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Drug Target Search – DistilBio Use Case
Over the past month I have been exploring DistilBio to look at specific use cases that would be useful to someone working in the area of drug discovery. I came up with several interesting and encouraging results. In this post, the first in this … Continue reading
Different strokes – Common painkillers and their mechanisms
We find a lot of over-the-counter (OTC) painkillers like aspirin, acetaminophen, ibuprofen. All these drugs though relieve pain and control fever, act in different ways and have different properties. I thought it would be interesting to look at how these … Continue reading →